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APAL
2010
97views more  APAL 2010»
15 years 4 months ago
A modal logic framework for reasoning about comparative distances and topology
We propose and investigate a uniform modal logic framework for reasoning about topology and relative distance in metric and more general distance spaces, thus enabling the compari...
Mikhail Sheremet, Frank Wolter, Michael Zakharyasc...
134
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BMCBI
2010
148views more  BMCBI 2010»
15 years 4 months ago
Applying unmixing to gene expression data for tumor phylogeny inference
Background: While in principle a seemingly infinite variety of combinations of mutations could result in tumor development, in practice it appears that most human cancers fall int...
Russell Schwartz, Stanley Shackney
BMCBI
2010
103views more  BMCBI 2010»
15 years 4 months ago
A method of predicting changes in human gene splicing induced by genetic variants in context of cis-acting elements
Background: Polymorphic variants and mutations disrupting canonical splicing isoforms are among the leading causes of human hereditary disorders. While there is a substantial evid...
Alexander G. Churbanov, Igor Vorechovsky, Chindo H...
BMCBI
2010
153views more  BMCBI 2010»
15 years 4 months ago
Starr: Simple Tiling ARRay analysis of Affymetrix ChIP-chip data
Background: Chromatin immunoprecipitation combined with DNA microarrays (ChIP-chip) is an assay used for investigating DNA-protein-binding or post-translational chromatin/histone ...
Benedikt Zacher, Pei Fen Kuan, Achim Tresch
BMCBI
2010
202views more  BMCBI 2010»
15 years 4 months ago
NeMo: Network Module identification in Cytoscape
Background: As the size of the known human interactome grows, biologists increasingly rely on computational tools to identify patterns that represent protein complexes and pathway...
Corban G. Rivera, Rachit Vakil, Joel S. Bader