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» Characterizations of postman sets
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BMCBI
2007
166views more  BMCBI 2007»
15 years 1 months ago
Optimization of filtering criterion for SEQUEST database searching to improve proteome coverage in shotgun proteomics
Background: In proteomic analysis, MS/MS spectra acquired by mass spectrometer are assigned to peptides by database searching algorithms such as SEQUEST. The assignations of pepti...
Xinning Jiang, Xiaogang Jiang, Guanghui Han, Mingl...
BMCBI
2007
157views more  BMCBI 2007»
15 years 1 months ago
Constructing gene co-expression networks and predicting functions of unknown genes by random matrix theory
Background: Large-scale sequencing of entire genomes has ushered in a new age in biology. One of the next grand challenges is to dissect the cellular networks consisting of many i...
Feng Luo, Yunfeng Yang, Jianxin Zhong, Haichun Gao...
BMCBI
2007
114views more  BMCBI 2007»
15 years 1 months ago
False occurrences of functional motifs in protein sequences highlight evolutionary constraints
Background: False occurrences of functional motifs in protein sequences can be considered as random events due solely to the sequence composition of a proteome. Here we use a nume...
Allegra Via, Pier Federico Gherardini, Enrico Ferr...
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BMCBI
2008
112views more  BMCBI 2008»
15 years 1 months ago
A simplified approach to disulfide connectivity prediction from protein sequences
Background: Prediction of disulfide bridges from protein sequences is useful for characterizing structural and functional properties of proteins. Several methods based on differen...
Marc Vincent, Andrea Passerini, Matthieu Labb&eacu...
BMCBI
2008
97views more  BMCBI 2008»
15 years 1 months ago
Interrogating domain-domain interactions with parsimony based approaches
Background: The identification and characterization of interacting domain pairs is an important step towards understanding protein interactions. In the last few years, several met...
Katia S. Guimarães, Teresa M. Przytycka