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» Classification of microarray data using gene networks
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BMCBI
2008
106views more  BMCBI 2008»
15 years 4 months ago
SpliceCenter: A suite of web-based bioinformatic applications for evaluating the impact of alternative splicing on RT-PCR, RNAi,
Background: Over 60% of protein-coding genes in vertebrates express mRNAs that undergo alternative splicing. The resulting collection of transcript isoforms poses significant chal...
Michael C. Ryan, Barry Zeeberg, Natasha J. Caplen,...
BIOINFORMATICS
2006
124views more  BIOINFORMATICS 2006»
15 years 4 months ago
Probabilistic inference of transcription factor concentrations and gene-specific regulatory activities
Motivation Quantitative estimation of the regulatory relationship between transcription factors and genes is a fundamental stepping stone when trying to develop models of cellular...
Guido Sanguinetti, Neil D. Lawrence, Magnus Rattra...
BMCBI
2004
165views more  BMCBI 2004»
15 years 3 months ago
Analysis of oligonucleotide array experiments with repeated measures using mixed models
Background: Two or more factor mixed factorial experiments are becoming increasingly common in microarray data analysis. In this case study, the two factors are presence (Patients...
Hao Li, Constance L. Wood, Thomas V. Getchell, Mar...
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CIBCB
2008
IEEE
15 years 10 months ago
Temporal and structural analysis of biological networks in combination with microarray data
— We introduce a graph-based relational learning approach using graph-rewriting rules for temporal and structural analysis of biological networks changing over time. The analysis...
Chang Hun You, Lawrence B. Holder, Diane J. Cook
BMCBI
2011
14 years 11 months ago
Identifying hypermethylated CpG islands using a quantile regression model
Background: DNA methylation has been shown to play an important role in the silencing of tumor suppressor genes in various tumor types. In order to have a system-wide understandin...
Shuying Sun, Zhengyi Chen, Pearlly Yan, Yi-Wen Hua...