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BMCBI
2006
120views more  BMCBI 2006»
15 years 4 months ago
Optimizing amino acid substitution matrices with a local alignment kernel
Background: Detecting remote homologies by direct comparison of protein sequences remains a challenging task. We had previously developed a similarity score between sequences, cal...
Hiroto Saigo, Jean-Philippe Vert, Tatsuya Akutsu
IDA
2008
Springer
15 years 4 months ago
Estimating the depth of anesthesia using fuzzy soft computation applied to EEG features
Estimating the depth of anesthesia (DOA) is still a challenging area in anesthesia research. The objective of this study was to design a fuzzy rule based system which integrates el...
V. Esmaeili, Amin Assareh, M. B. Shamsollahi, Moha...
BMCBI
2006
117views more  BMCBI 2006»
15 years 4 months ago
Gene Designer: a synthetic biology tool for constructing artificial DNA segments
Background: Direct synthesis of genes is rapidly becoming the most efficient way to make functional genetic constructs and enables applications such as codon optimization, RNAi re...
Alan Villalobos, Jon E. Ness, Claes Gustafsson, Je...
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BMCBI
2006
137views more  BMCBI 2006»
15 years 4 months ago
A maximum likelihood framework for protein design
Background: The aim of protein design is to predict amino-acid sequences compatible with a given target structure. Traditionally envisioned as a purely thermodynamic question, thi...
Claudia L. Kleinman, Nicolas Rodrigue, Céci...
BMCBI
2006
116views more  BMCBI 2006»
15 years 4 months ago
ROKU: a novel method for identification of tissue-specific genes
Background: One of the important goals of microarray research is the identification of genes whose expression is considerably higher or lower in some tissues than in others. We wo...
Koji Kadota, Jiazhen Ye, Yuji Nakai, Tohru Terada,...