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ICMLA
2010
14 years 7 months ago
Smoothing Gene Expression Using Biological Networks
Gene expression (microarray) data have been used widely in bioinformatics. The expression data of a large number of genes from small numbers of subjects are used to identify inform...
Yue Fan, Mark A. Kon, Shinuk Kim, Charles DeLisi
BMCBI
2006
119views more  BMCBI 2006»
14 years 9 months ago
LS-NMF: A modified non-negative matrix factorization algorithm utilizing uncertainty estimates
Background: Non-negative matrix factorisation (NMF), a machine learning algorithm, has been applied to the analysis of microarray data. A key feature of NMF is the ability to iden...
Guoli Wang, Andrew V. Kossenkov, Michael F. Ochs
BIOINFORMATICS
2007
137views more  BIOINFORMATICS 2007»
14 years 9 months ago
Annotation-based distance measures for patient subgroup discovery in clinical microarray studies
: Background Clustering algorithms are widely used in the analysis of microarray data. In clinical studies, they are often applied to find groups of co-regulated genes. Clustering...
Claudio Lottaz, Joern Toedling, Rainer Spang
85
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BMCBI
2007
147views more  BMCBI 2007»
14 years 9 months ago
Statistical analysis and significance testing of serial analysis of gene expression data using a Poisson mixture model
Background: Serial analysis of gene expression (SAGE) is used to obtain quantitative snapshots of the transcriptome. These profiles are count-based and are assumed to follow a Bin...
Scott D. Zuyderduyn
SDM
2007
SIAM
98views Data Mining» more  SDM 2007»
14 years 11 months ago
Lattice based Clustering of Temporal Gene-Expression Matrices
Individuals show different cell classes when they are in the different stages of a disease, have different disease subtypes, or have different response to a treatment or envir...
Yang Huang, Martin Farach-Colton