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98
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BMCBI
2006
123views more  BMCBI 2006»
14 years 11 months ago
Characterizing disease states from topological properties of transcriptional regulatory networks
Background: High throughput gene expression experiments yield large amounts of data that can augment our understanding of disease processes, in addition to classifying samples. He...
David Tuck, Harriet Kluger, Yuval Kluger
BMCBI
2006
94views more  BMCBI 2006»
14 years 11 months ago
Fly-DPI: database of protein interactomes for D. melanogaster in the approach of systems biology
Background: Proteins control and mediate many biological activities of cells by interacting with other protein partners. This work presents a statistical model to predict protein ...
Chung-Yen Lin, Shu-Hwa Chen, Chi-Shiang Cho, Chia-...
BMCBI
2006
103views more  BMCBI 2006»
14 years 11 months ago
Cis-motifs upstream of the transcription and translation initiation sites are effectively revealed by their positional disequili
Background: The discovery of cis-regulatory motifs still remains a challenging task even though the number of sequenced genomes is constantly growing. Computational analyses using...
Kenneth W. Berendzen, Kurt Stüber, Klaus Hart...
BMCBI
2006
136views more  BMCBI 2006»
14 years 11 months ago
Java GUI for InterProScan (JIPS): A tool to help process multiple InterProScans and perform ortholog analysis
Background: Recent, rapid growth in the quantity of available genomic data has generated many protein sequences that are not yet biochemically classified. Thus, the prediction of ...
Aijazuddin Syed, Chris Upton
117
Voted
BMCBI
2006
116views more  BMCBI 2006»
14 years 11 months ago
Cluster analysis for DNA methylation profiles having a detection threshold
Background: DNA methylation, a molecular feature used to investigate tumor heterogeneity, can be measured on many genomic regions using the MethyLight technology. Due to the combi...
Paul Marjoram, Jing Chang, Peter W. Laird, Kimberl...