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» Combinatorics of RNA Secondary Structures
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IWOCA
2010
Springer
219views Algorithms» more  IWOCA 2010»
14 years 4 months ago
Efficient Chaining of Seeds in Ordered Trees
We consider here the problem of chaining seeds in ordered trees. Seeds are mappings between two trees Q and T and a chain is a subset of non overlapping seeds that is consistent wi...
Julien Allali, Cedric Chauve, Pascal Ferraro, Anne...
BMCBI
2007
165views more  BMCBI 2007»
14 years 9 months ago
Ab initio identification of human microRNAs based on structure motifs
Background: MicroRNAs (miRNAs) are short, non-coding RNA molecules that are directly involved in post-transcriptional regulation of gene expression. The mature miRNA sequence bind...
Markus Brameier, Carsten Wiuf
71
Voted
BMCBI
2006
82views more  BMCBI 2006»
14 years 9 months ago
Selection of antisense oligonucleotides based on multiple predicted target mRNA structures
Background: Local structures of target mRNAs play a significant role in determining the efficacies of antisense oligonucleotides (ODNs), but some structure-based target site selec...
Xiaochen Bo, Shaoke Lou, Daochun Sun, Wenjie Shu, ...
WABI
2005
Springer
120views Bioinformatics» more  WABI 2005»
15 years 2 months ago
Multiple Structural RNA Alignment with Lagrangian Relaxation
In contrast to proteins, many classes of functionally related RNA molecules show a rather weak sequence conservation but instead a fairly well conserved secondary structure. Hence ...
Markus Bauer, Gunnar W. Klau, Knut Reinert
70
Voted
BMCBI
2007
94views more  BMCBI 2007»
14 years 9 months ago
A structural analysis of in vitro catalytic activities of hammerhead ribozymes
Background: Ribozymes are small catalytic RNAs that possess the dual functions of sequencespecific RNA recognition and site-specific cleavage. Trans-cleaving ribozymes can inhibit...
Yu Shao, Susan Wu, Chi Yu Chan, Jessie R. Klapper,...