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BMCBI
2008
118views more  BMCBI 2008»
14 years 9 months ago
Evaluation of phylogenetic footprint discovery for predicting bacterial cis-regulatory elements and revealing their evolution
Background: The detection of conserved motifs in promoters of orthologous genes (phylogenetic footprints) has become a common strategy to predict cis-acting regulatory elements. S...
Rekin's Janky, Jacques van Helden
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BMCBI
2010
108views more  BMCBI 2010»
14 years 9 months ago
An intuitionistic approach to scoring DNA sequences against transcription factor binding site motifs
Background: Transcription factors (TFs) control transcription by binding to specific regions of DNA called transcription factor binding sites (TFBSs). The identification of TFBSs ...
Fernando Garcia-Alcalde, Armando Blanco, Adrian J....
BMCBI
2008
123views more  BMCBI 2008»
14 years 9 months ago
Validation of protein models by a neural network approach
Background: The development and improvement of reliable computational methods designed to evaluate the quality of protein models is relevant in the context of protein structure re...
Paolo Mereghetti, Maria Luisa Ganadu, Elena Papale...
BMCBI
2008
110views more  BMCBI 2008»
14 years 9 months ago
Testing for treatment effects on gene ontology
In studies that use DNA arrays to assess changes in gene expression, it is preferable to measure the significance of treatment effects on a group of genes from a pathway or functi...
Taewon Lee, Varsha G. Desai, Cruz Velasco, Robert ...
CSDA
2008
128views more  CSDA 2008»
14 years 9 months ago
Classification tree analysis using TARGET
Tree models are valuable tools for predictive modeling and data mining. Traditional tree-growing methodologies such as CART are known to suffer from problems including greediness,...
J. Brian Gray, Guangzhe Fan