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FSTTCS
2003
Springer
15 years 2 months ago
Comparing Sequences with Segment Rearrangements
Computational genomics involves comparing sequences based on “similarity” for detecting evolutionary and functional relationships. Until very recently, available portions of th...
Funda Ergün, S. Muthukrishnan, Süleyman ...
CSB
2005
IEEE
132views Bioinformatics» more  CSB 2005»
14 years 11 months ago
A Fast Shotgun Assembly Heuristic
Genome sequencing opened a new era in genetics allowing the study of genomes at the nucleotide level. However, the chosen method of sequencing produced large numbers of nucleotide...
Christopher Wilks, Sami Khuri
WABI
2004
Springer
15 years 2 months ago
Chaining Algorithms for Alignment of Draft Sequence
Abstract. In this paper we propose a chaining method that can align a draft genomic sequence against a finished genome. We introduce the use of an overlap tree to enhance the state...
Mukund Sundararajan, Michael Brudno, Kerrin Small,...
BMCBI
2007
123views more  BMCBI 2007»
14 years 9 months ago
Tracembler - software for in-silico chromosome walking in unassembled genomes
Background: Whole genome shotgun sequencing produces increasingly higher coverage of a genome with random sequence reads. Progressive whole genome assembly and eventual finishing ...
Qunfeng Dong, Matthew D. Wilkerson, Volker Brendel
WABI
2007
Springer
139views Bioinformatics» more  WABI 2007»
15 years 3 months ago
Computability of Models for Sequence Assembly
Graph-theoretic models have come to the forefront as some of the most powerful and practical methods for sequence assembly. Simultaneously, the computational hardness of the underl...
Paul Medvedev, Konstantinos Georgiou, Gene Myers, ...