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BMCBI
2010
14 years 9 months ago
2010
Background: Polymorphic variants and mutations disrupting canonical splicing isoforms are among the leading causes of human hereditary disorders. While there is a substantial evid...
BMCBI
2010
14 years 9 months ago
2010
Background: The Ensembl web site has provided access to genomic information for almost 10 years. During this time the amount of data available through Ensembl has grown dramatical...
BMCBI
2010
14 years 9 months ago
2010
Background: Prediction of catalytic residues is a major step in characterizing the function of enzymes. In its simpler formulation, the problem can be cast into a binary classific...
BMCBI
2010
14 years 9 months ago
2010
Background: While microarrays are the predominant method for gene expression profiling, probe signal variation is still an area of active research. Probe signal is sequence depend...
BMCBI
2010
14 years 9 months ago
2010
Background: High-throughput sequencing technologies, such as the Illumina Genome Analyzer, are powerful new tools for investigating a wide range of biological and medical question...