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» Comparative genome assembly
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117
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NAR
2006
142views more  NAR 2006»
15 years 12 days ago
miRNAMap: genomic maps of microRNA genes and their target genes in mammalian genomes
Recent work has demonstrated that microRNAs (miRNAs) are involved in critical biological processes by suppressing the translation of coding genes. This work develops an integrated...
Paul Wei-Che Hsu, Hsien-Da Huang, Sheng-Da Hsu, Li...
ESA
2001
Springer
105views Algorithms» more  ESA 2001»
15 years 5 months ago
SNPs Problems, Complexity, and Algorithms
Abstract. Single nucleotide polymorphisms (SNPs) are the most frequent form of human genetic variation. They are of fundamental importance for a variety of applications including m...
Giuseppe Lancia, Vineet Bafna, Sorin Istrail, Ross...
90
Voted
BMCBI
2008
138views more  BMCBI 2008»
15 years 18 days ago
Automated simultaneous analysis phylogenetics (ASAP): an enabling tool for phlyogenomics
Background: The availability of sequences from whole genomes to reconstruct the tree of life has the potential to enable the development of phylogenomic hypotheses in ways that ha...
Indra Neil Sarkar, Mary G. Egan, Gloria M. Coruzzi...
123
Voted
BMCBI
2007
113views more  BMCBI 2007»
15 years 14 days ago
Statistical power of phylo-HMM for evolutionarily conserved element detection
Background: An important goal of comparative genomics is the identification of functional elements through conservation analysis. Phylo-HMM was recently introduced to detect conse...
Xiaodan Fan, Jun Zhu, Eric E. Schadt, Jun S. Liu
BMCBI
2011
14 years 7 months ago
Screening synteny blocks in pairwise genome comparisons through integer programming
Background: It is difficult to accurately interpret chromosomal correspondences such as true orthology and paralogy due to significant divergence of genomes from a common ancestor...
Haibao Tang, Eric Lyons, Brent S. Pedersen, James ...