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BMCBI
2006
165views more  BMCBI 2006»
14 years 11 months ago
Validation and functional annotation of expression-based clusters based on gene ontology
Background: The biological interpretation of large-scale gene expression data is one of the paramount challenges in current bioinformatics. In particular, placing the results in t...
Ralf Steuer, Peter Humburg, Joachim Selbig
CCE
2007
14 years 11 months ago
Adaptive optimisation of noisy black-box functions inherent in microscopic models
For systems where exact constitutive relations are unknown, a microscopic level description can be alternatively used. As microscopic simulations are computationally expensive, th...
Eddie Davis, Marianthi G. Ierapetritou
BMCBI
2010
195views more  BMCBI 2010»
14 years 6 months ago
MBAT: A scalable informatics system for unifying digital atlasing workflows
Background: Digital atlases provide a common semantic and spatial coordinate system that can be leveraged to compare, contrast, and correlate data from disparate sources. As the q...
Daren Lee, Seth Ruffins, Queenie Ng, Nikhil Sane, ...
BMCBI
2007
233views more  BMCBI 2007»
14 years 11 months ago
160-fold acceleration of the Smith-Waterman algorithm using a field programmable gate array (FPGA)
Background: To infer homology and subsequently gene function, the Smith-Waterman (SW) algorithm is used to find the optimal local alignment between two sequences. When searching s...
Isaac T. S. Li, Warren Shum, Kevin Truong
RECOMB
2006
Springer
16 years 7 hour ago
Identifiability Issues in Phylogeny-Based Detection of Horizontal Gene Transfer
Prokaryotic organisms share genetic material across species boundaries by means of a process known as horizontal gene transfer (HGT). Detecting this process bears great significanc...
Cuong Than, Derek A. Ruths, Hideki Innan, Luay Nak...