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BMCBI
2008
97views more  BMCBI 2008»
15 years 4 months ago
A Population Proportion approach for ranking differentially expressed genes
Background: DNA microarrays are used to investigate differences in gene expression between two or more classes of samples. Most currently used approaches compare mean expression l...
Mugdha Gadgil
BMCBI
2008
105views more  BMCBI 2008»
15 years 4 months ago
Using the longest significance run to estimate region-specific p-values in genetic association mapping studies
Background: Association testing is a powerful tool for identifying disease susceptibility genes underlying complex diseases. Technological advances have yielded a dramatic increas...
Ie-Bin Lian, Yi-Hsien Lin, Ying-Chao Lin, Hsin-Cho...
BMCBI
2008
145views more  BMCBI 2008»
15 years 4 months ago
The contrasting properties of conservation and correlated phylogeny in protein functional residue prediction
Background: Amino acids responsible for structure, core function or specificity may be inferred from multiple protein sequence alignments where a limited set of residue types are ...
Jonathan R. Manning, Emily R. Jefferson, Geoffrey ...
BMCBI
2008
154views more  BMCBI 2008»
15 years 4 months ago
Extension of the COG and arCOG databases by amino acid and nucleotide sequences
Background: The current versions of the COG and arCOG databases, both excellent frameworks for studies in comparative and functional genomics, do not contain the nucleotide sequen...
Florian Meereis, Michael Kaufmann
BMCBI
2008
208views more  BMCBI 2008»
15 years 4 months ago
GraphFind: enhancing graph searching by low support data mining techniques
Background: Biomedical and chemical databases are large and rapidly growing in size. Graphs naturally model such kinds of data. To fully exploit the wealth of information in these...
Alfredo Ferro, Rosalba Giugno, Misael Mongiov&igra...