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BMCBI
2006
137views more  BMCBI 2006»
15 years 4 months ago
Sigma: multiple alignment of weakly-conserved non-coding DNA sequence
Background: Existing tools for multiple-sequence alignment focus on aligning protein sequence or protein-coding DNA sequence, and are often based on extensions to Needleman-Wunsch...
Rahul Siddharthan
BMCBI
2006
211views more  BMCBI 2006»
15 years 4 months ago
Missing value estimation for DNA microarray gene expression data by Support Vector Regression imputation and orthogonal coding s
Background: Gene expression profiling has become a useful biological resource in recent years, and it plays an important role in a broad range of areas in biology. The raw gene ex...
Xian Wang, Ao Li, Zhaohui Jiang, Huanqing Feng
BMCBI
2006
165views more  BMCBI 2006»
15 years 4 months ago
A stable gene selection in microarray data analysis
Background: Microarray data analysis is notorious for involving a huge number of genes compared to a relatively small number of samples. Gene selection is to detect the most signi...
Kun Yang, Zhipeng Cai, Jianzhong Li, Guohui Lin
BMCBI
2006
139views more  BMCBI 2006»
15 years 4 months ago
DNA Molecule Classification Using Feature Primitives
Background: We present a novel strategy for classification of DNA molecules using measurements from an alpha-Hemolysin channel detector. The proposed approach provides excellent c...
Raja Tanveer Iqbal, Matthew Landry, Stephen Winter...
BMCBI
2006
117views more  BMCBI 2006»
15 years 4 months ago
The Cluster Variation Method for Efficient Linkage Analysis on Extended Pedigrees
Background: Computing exact multipoint LOD scores for extended pedigrees rapidly becomes infeasible as the number of markers and untyped individuals increase. When markers are exc...
Cornelis A. Albers, Martijn A. R. Leisink, Hilbert...