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140
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CEC
2011
IEEE
14 years 29 days ago
Comparing alternative energy functions for the HP model of protein structure prediction
Abstract—Protein structure prediction is the problem of finding the functional conformation of a protein given only its amino uence. The HP lattice model is an abstract formulat...
Mario Garza-Fabre, Eduardo Rodriguez-Tello, Gregor...
135
Voted
EVOW
2012
Springer
13 years 8 months ago
Multiobjectivizing the HP Model for Protein Structure Prediction
Abstract. The hydrophobic-polar (HP) model for protein structure preabstracts the fact that hydrophobic interactions are a dominant force in the protein folding process. This model...
Mario Garza-Fabre, Eduardo Rodriguez-Tello, Gregor...
118
Voted
BMCBI
2007
216views more  BMCBI 2007»
15 years 1 months ago
A replica exchange Monte Carlo algorithm for protein folding in the HP model
Background: The ab initio protein folding problem consists of predicting protein tertiary structure from a given amino acid sequence by minimizing an energy function; it is one of...
Chris Thachuk, Alena Shmygelska, Holger H. Hoos
127
Voted
AE
2005
Springer
15 years 6 months ago
An Enhanced Genetic Algorithm for Protein Structure Prediction Using the 2D Hydrophobic-Polar Model
This paper presents an enhanced genetic algorithm for the protein structure prediction problem. A new fitness function, that uses the concept of radius of gyration, is proposed. Al...
Heitor S. Lopes, Marcos P. Scapin
111
Voted
BMCBI
2006
165views more  BMCBI 2006»
15 years 1 months ago
Improving the quality of protein structure models by selecting from alignment alternatives
Background: In the area of protein structure prediction, recently a lot of effort has gone into the development of Model Quality Assessment Programs (MQAPs). MQAPs distinguish hig...
Ingolf Sommer, Stefano Toppo, Oliver Sander, Thoma...