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BMCBI
2008
116views more  BMCBI 2008»
15 years 3 months ago
A novel representation of RNA secondary structure based on element-contact graphs
Background: Depending on their specific structures, noncoding RNAs (ncRNAs) play important roles in many biological processes. Interest in developing new topological indices based...
Wenjie Shu, Xiaochen Bo, Zhiqiang Zheng, Shengqi W...
BMCBI
2010
119views more  BMCBI 2010»
15 years 3 months ago
A comparison of internal validation techniques for multifactor dimensionality reduction
Background: It is hypothesized that common, complex diseases may be due to complex interactions between genetic and environmental factors, which are difficult to detect in high-di...
Stacey J. Winham, Andrew J. Slater, Alison A. Mots...
118
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BMCBI
2010
100views more  BMCBI 2010»
15 years 3 months ago
Efficiency clustering for low-density microarrays and its application to QPCR
Background: Pathway-targeted or low-density arrays are used more and more frequently in biomedical research, particularly those arrays that are based on quantitative real-time PCR...
Eric F. Lock, Ryan Ziemiecki, J. S. Marron, Dirk P...
124
Voted
BMCBI
2007
152views more  BMCBI 2007»
15 years 3 months ago
Bioinformatic identification of novel putative photoreceptor specific cis-elements
Background: Cell specific gene expression is largely regulated by different combinations of transcription factors that bind cis-elements in the upstream promoter sequence. However...
Charles G. Danko, Vera A. McIlvain, Maochun Qin, B...
124
Voted
BMCBI
2010
125views more  BMCBI 2010»
15 years 3 months ago
Compartmentalization of the Edinburgh Human Metabolic Network
Background: Direct in vivo investigation of human metabolism is complicated by the distinct metabolic functions of various sub-cellular organelles. Diverse micro-environments in d...
Tong Hao, Hongwu Ma, Xue-Ming Zhao, Igor Goryanin