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ALIFE
2006
15 years 13 days ago
The Origin of the Eukaryotic Cell Based on Conservation of Existing Interfaces
Current theories about the origin of the eukaryotic cell all assume that during evolution a prokaryotic cell acquired a nucleus. Here, it is shown that a scenario in which the nucl...
Albert D. G. de Roos
100
Voted
BMCBI
2010
105views more  BMCBI 2010»
15 years 15 days ago
Predicting phenotypic traits of prokaryotes from protein domain frequencies
Background: Establishing the relationship between an organism's genome sequence and its phenotype is a fundamental challenge that remains largely unsolved. Accurately predict...
Thomas Lingner, Stefanie Mühlhausen, Toni Gab...
112
Voted
NAR
2011
195views Computer Vision» more  NAR 2011»
14 years 3 months ago
MitoGenesisDB: an expression data mining tool to explore spatio-temporal dynamics of mitochondrial biogenesis
Mitochondria constitute complex and flexible cellular entities, which play crucial roles in normal and pathological cell conditions. The database MitoGenesisDB focuses on the dyna...
Jean-Christophe Gelly, Mickael Orgeur, Claude Jacq...
122
Voted
RECOMB
1999
Springer
15 years 4 months ago
Evolution of metabolisms: a new method for the comparison of metabolic pathways
The abundance of information provided by completely sequenced genomes de nes a starting point for new insights in the multilevel organization of organisms and their evolution. At ...
Christian V. Forst, Klaus Schulten
BMCBI
2006
108views more  BMCBI 2006»
15 years 13 days ago
NOXclass: prediction of protein-protein interaction types
Background: Structural models determined by X-ray crystallography play a central role in understanding protein-protein interactions at the molecular level. Interpretation of these...
Hongbo Zhu, Francisco S. Domingues, Ingolf Sommer,...