Background: Signal transduction pathways are usually modelled using classical quantitative methods, which are based on ordinary differential equations (ODEs). However, some diffic...
Background: The emerging field of integrative bioinformatics provides the tools to organize and systematically analyze vast amounts of highly diverse biological data and thus allo...
Markus Fischer, Quan K. Thai, Melanie Grieb, J&uum...
Background: DNA methylation plays an important role in development and tumorigenesis by epigenetic modification and silencing of critical genes. The development of PCR-based methy...
Filip Pattyn, Jasmien Hoebeeck, Piet Robbrecht, Ev...
Background: The use of exogenous small interfering RNAs (siRNAs) for gene silencing has quickly become a widespread molecular tool providing a powerful means for gene functional s...
Jean-Philippe Vert, Nicolas Foveau, Christian Laja...
Background: Gene function analysis often requires a complex and laborious sequence of laboratory and computer-based experiments. Choosing an effective experimental design generall...
Oliver Laule, Matthias Hirsch-Hoffmann, Tomas Hruz...