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115
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WCRE
2003
IEEE
15 years 5 months ago
Toward an environment for comprehending distributed systems
Many modern software systems are often large, distributed, written in more than one programming language, and developed using pre-built components. This paper presents the results...
Maher Salah, Spiros Mancoridis
CRIWG
2004
15 years 1 months ago
A Decoupled Architecture for Action-Oriented Coordination and Awareness Management in CSCL/W Frameworks
This paper introduces AORTA, a software architecture that provides object-level coordination and shared workspace awareness support to synchronous and distributed collaborative app...
Pablo Orozco, Juan I. Asensio-Pérez, Pedro ...
116
Voted
RECOMB
2002
Springer
16 years 23 days ago
From promoter sequence to expression: a probabilistic framework
We present a probabilistic framework that models the process by which transcriptional binding explains the mRNA expression of different genes. Our joint probabilistic model unifie...
Eran Segal, Yoseph Barash, Itamar Simon, Nir Fried...
83
Voted
BMCBI
2006
137views more  BMCBI 2006»
15 years 15 days ago
A maximum likelihood framework for protein design
Background: The aim of protein design is to predict amino-acid sequences compatible with a given target structure. Traditionally envisioned as a purely thermodynamic question, thi...
Claudia L. Kleinman, Nicolas Rodrigue, Céci...
BMCBI
2010
122views more  BMCBI 2010»
15 years 17 days ago
An automated framework for understanding structural variations in the binding grooves of MHC class II molecules
Background: MHC/HLA class II molecules are important components of the immune system and play a critical role in processes such as phagocytosis. Understanding peptide recognition ...
Kalidas Yeturu, Tapani Utriainen, Graham J. L. Kem...