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BMCBI
2004
146views more  BMCBI 2004»
14 years 9 months ago
Multivariate search for differentially expressed gene combinations
Background: To identify differentially expressed genes, it is standard practice to test a twosample hypothesis for each gene with a proper adjustment for multiple testing. Such te...
Yuanhui Xiao, Robert D. Frisina, Alexander Gordon,...
BMCBI
2007
114views more  BMCBI 2007»
14 years 10 months ago
Mining and state-space modeling and verification of sub-networks from large-scale biomolecular networks
Background: Biomolecular networks dynamically respond to stimuli and implement cellular function. Understanding these dynamic changes is the key challenge for cell biologists. As ...
Xiaohua Hu, Fang-Xiang Wu
WABI
2009
Springer
128views Bioinformatics» more  WABI 2009»
15 years 4 months ago
Improving Inference of Transcriptional Regulatory Networks Based on Network Evolutionary Models
Abstract. Computational inference of transcriptional regulatory networks remains a challenging problem, in part due to the lack of strong network models. In this paper we present e...
Xiuwei Zhang, Bernard M. E. Moret
IWANN
2009
Springer
15 years 4 months ago
GREAT: Gene Regulation EvAluation Tool
Our understanding of biological systems is highly dependent on the study of the mechanisms that regulate genetic expression. In this paper we present a tool to evaluate scientific ...
Catia Machado, Hugo P. Bastos, Francisco M. Couto
RECOMB
2009
Springer
15 years 10 months ago
A Robust Bayesian Two-Sample Test for Detecting Intervals of Differential Gene Expression in Microarray Time Series
Abstract. Understanding the regulatory mechanisms that are responsible for an organism's response to environmental changes is an important question in molecular biology. A fir...
Oliver Stegle, Katherine J. Denby, David L. Wild, ...