Background: We consider the problem of parameter estimation (model calibration) in nonlinear dynamic models of biological systems. Due to the frequent ill-conditioning and multi-m...
Maria Rodriguez-Fernandez, Jose A. Egea, Julio R. ...
Integration of heterogeneous data types is a challenging problem, especially in biology, where the number of databases and data types increase rapidly. Amongst the problems that o...
Models will play a central role in the representation, storage, manipulation, and communication of knowledge in systems biology. Models capable of fulfilling such a role will like...
Computational grids and grid middleware offer unprecedented computational power and storage capacity, and thus, have opened the possibility of solving problems that were previousl...
Suchuan Dong, Nicholas T. Karonis, George E. Karni...
Abstract--Today's molecular biology is confronted with enormous amounts of data, generated by new high-throughput technologies, along with an increasing number of biological m...