Background: Semantic similarity measures are useful to assess the physiological relevance of protein-protein interactions (PPIs). They quantify similarity between proteins based o...
Randomness is inherent to biochemistry: at each instant, the sequence of reactions that fires is a matter of chance. Some biological systems exploit such randomness, choosing betw...
Background: The availability of complete genomic sequences for hundreds of organisms promises to make obtaining genome-wide estimates of substitution rates, selective constraints ...
Amy Egan, Anup Mahurkar, Jonathan Crabtree, Jonath...
Experimental time courses often reveal a nonlinear behaviour. Analysing these nonlinearities is even more challenging when the observed phenomenon is cyclic or oscillatory. This me...
With the exponential growth of complete genome sequences, the analysis of these sequences is becoming a powerful approach to build genome-scale metabolic models. These models can ...