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» Computational epigenetics
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RECOMB
2012
Springer
13 years 1 months ago
A Model for Biased Fractionation after Whole Genome Duplication
Background: Paralog reduction, the loss of duplicate genes after whole genome duplication (WGD) is a pervasive process. Whether this loss proceeds gene by gene or through deletion...
David Sankoff, Chunfang Zheng, Baoyong Wang
BMCBI
2008
155views more  BMCBI 2008»
14 years 11 months ago
Prediction of regulatory elements in mammalian genomes using chromatin signatures
Background: Recent genomic scale survey of epigenetic states in the mammalian genomes has shown that promoters and enhancers are correlated with distinct chromatin signatures, pro...
Kyoung-Jae Won, Iouri Chepelev, Bing Ren, Wei Wang
BMCBI
2008
135views more  BMCBI 2008»
14 years 11 months ago
Identification of a small optimal subset of CpG sites as bio-markers from high-throughput DNA methylation profiles
Background: DNA methylation patterns have been shown to significantly correlate with different tissue types and disease states. High-throughput methylation arrays enable large-sca...
Hailong Meng, Edward Lenn Murrelle, Guoya Li
BMCBI
2008
160views more  BMCBI 2008»
14 years 11 months ago
Predicting cancer involvement of genes from heterogeneous data
Background: Systematic approaches for identifying proteins involved in different types of cancer are needed. Experimental techniques such as microarrays are being used to characte...
Ramon Aragues, Chris Sander, Baldo Oliva