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BMCBI
2008
87views more  BMCBI 2008»
15 years 4 months ago
Identification of deleterious non-synonymous single nucleotide polymorphisms using sequence-derived information
Background: As the number of non-synonymous single nucleotide polymorphisms (nsSNPs), also known as single amino acid polymorphisms (SAPs), increases rapidly, computational method...
Jing Hu, Changhui Yan
BMCBI
2008
122views more  BMCBI 2008»
15 years 4 months ago
Generating samples for association studies based on HapMap data
Background: With the completion of the HapMap project, a variety of computational algorithms and tools have been proposed for haplotype inference, tag SNP selection and genome-wid...
Jing Li, Yixuan Chen
BMCBI
2010
227views more  BMCBI 2010»
15 years 4 months ago
Accurate and efficient gp120 V3 loop structure based models for the determination of HIV-1 co-receptor usage
Background: HIV-1 targets human cells expressing both the CD4 receptor, which binds the viral envelope glycoprotein gp120, as well as either the CCR5 (R5) or CXCR4 (X4) co-recepto...
Majid Masso, Iosif I. Vaisman
BMCBI
2007
114views more  BMCBI 2007»
15 years 4 months ago
Mining and state-space modeling and verification of sub-networks from large-scale biomolecular networks
Background: Biomolecular networks dynamically respond to stimuli and implement cellular function. Understanding these dynamic changes is the key challenge for cell biologists. As ...
Xiaohua Hu, Fang-Xiang Wu
BMCBI
2010
189views more  BMCBI 2010»
15 years 4 months ago
Efficient parallel and out of core algorithms for constructing large bi-directed de Bruijn graphs
Background: Assembling genomic sequences from a set of overlapping reads is one of the most fundamental problems in computational biology. Algorithms addressing the assembly probl...
Vamsi Kundeti, Sanguthevar Rajasekaran, Hieu Dinh,...
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