Background: Comparative genomics aims to detect signals of evolutionary conservation as an indicator of functional constraint. Surprisingly, results of the ENCODE project revealed...
Background: There are many important clustering questions in computational biology for which no satisfactory method exists. Automated clustering algorithms, when applied to large,...
Background: Amino acid sequence probability distributions, or profiles, have been used successfully to predict secondary structure and local structure in proteins. Profile models ...
Background: Although the prediction of protein-protein interactions has been extensively investigated for yeast, few such datasets exist for the far larger proteome in human. Furt...
Background: Comprehensively understanding corticosteroid pharmacogenomic effects is an essential step towards an insight into the underlying molecular mechanisms for both benefici...
Tung T. Nguyen, Richard R. Almon, Debra C. DuBois,...