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108
Voted
BMCBI
2010
15 years 3 months ago
2010
Background: Bacterial infections represent a global health challenge. The identification of novel antibacterial targets for both therapy and vaccination is needed on a constant ba...
129
Voted
BMCBI
2010
15 years 3 months ago
2010
Background: Large genomes contain families of highly similar genes that cannot be individually identified by microarray probes. This limitation is due to thermodynamic restriction...
111
Voted
BMCBI
2010
15 years 3 months ago
2010
Background: Alternative splicing is an important mechanism that increases protein diversity and functionality in higher eukaryotes. Affymetrix exon arrays are a commercialized pla...
103
Voted
BMCBI
2010
15 years 3 months ago
2010
Background: The success achieved by genome-wide association (GWA) studies in the identification of candidate loci for complex diseases has been accompanied by an inability to expl...
151
Voted
BMCBI
2010
15 years 3 months ago
2010
Background: Methylation of CpG islands within the DNA promoter regions is one mechanism that leads to aberrant gene expression in cancer. In particular, the abnormal methylation o...