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103
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ALMOB
2007
170views more  ALMOB 2007»
14 years 10 months ago
A spatio-temporal mining approach towards summarizing and analyzing protein folding trajectories
Understanding the protein folding mechanism remains a grand challenge in structural biology. In the past several years, computational theories in molecular dynamics have been empl...
Hui Yang, Srinivasan Parthasarathy, Duygu Ucar
BMCBI
2010
174views more  BMCBI 2010»
14 years 10 months ago
The effect of prior assumptions over the weights in BayesPI with application to study protein-DNA interactions from ChIP-based h
Background: To further understand the implementation of hyperparameters re-estimation technique in Bayesian hierarchical model, we added two more prior assumptions over the weight...
Junbai Wang
74
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BMCBI
2008
160views more  BMCBI 2008»
14 years 10 months ago
Dynamic sensitivity analysis of biological systems
Background: A mathematical model to understand, predict, control, or even design a real biological system is a central theme in systems biology. A dynamic biological system is alw...
Wu Hsiung Wu, Feng Sheng Wang, Maw Shang Chang
CORR
2010
Springer
205views Education» more  CORR 2010»
14 years 10 months ago
Behavioral Simulations in MapReduce
In many scientific domains, researchers are turning to large-scale behavioral simulations to better understand real-world phenomena. While there has been a great deal of work on s...
Guozhang Wang, Marcos Antonio Vaz Salles, Benjamin...
101
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BMCBI
2006
175views more  BMCBI 2006»
14 years 10 months ago
Parameter estimation for stiff equations of biosystems using radial basis function networks
Background: The modeling of dynamic systems requires estimating kinetic parameters from experimentally measured time-courses. Conventional global optimization methods used for par...
Yoshiya Matsubara, Shinichi Kikuchi, Masahiro Sugi...