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BMCBI
2004
131views more  BMCBI 2004»
14 years 11 months ago
Alternative mapping of probes to genes for Affymetrix chips
Background: Short oligonucleotide arrays have several probes measuring the expression level of each target transcript. Therefore the selection of probes is a key component for the...
Laurent Gautier, Morten Møller, Lennart Fri...
BMCBI
2004
125views more  BMCBI 2004»
14 years 11 months ago
A functional hierarchical organization of the protein sequence space
Background: It is a major challenge of computational biology to provide a comprehensive functional classification of all known proteins. Most existing methods seek recurrent patte...
Noam Kaplan, Moriah Friedlich, Menachem Fromer, Mi...
BMCBI
2004
151views more  BMCBI 2004»
14 years 11 months ago
Design, implementation and evaluation of a practical pseudoknot folding algorithm based on thermodynamics
Background: The general problem of RNA secondary structure prediction under the widely used thermodynamic model is known to be NP-complete when the structures considered include a...
Jens Reeder, Robert Giegerich
BMCBI
2004
173views more  BMCBI 2004»
14 years 11 months ago
d-matrix - database exploration, visualization and analysis
Background: Motivated by a biomedical database set up by our group, we aimed to develop a generic database front-end with embedded knowledge discovery and analysis features. A maj...
Dominik Seelow, Raffaello Galli, Siegrun Mebus, Ha...
BMCBI
2004
112views more  BMCBI 2004»
14 years 11 months ago
A double classification tree search algorithm for index SNP selection
Background: In population-based studies, it is generally recognized that single nucleotide polymorphism (SNP) markers are not independent. Rather, they are carried by haplotypes, ...
Peisen Zhang, Huitao Sheng, Ryuhei Uehara