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» Computing persistent homology
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BMCBI
2011
14 years 4 months ago
CODA (CrossOver Distribution Analyzer): quantitative characterization of crossover position patterns along chromosomes
Background: During meiosis, homologous chromosomes exchange segments via the formation of crossovers. This phenomenon is highly regulated; in particular, crossovers are distribute...
Franck Gauthier, Olivier C. Martin, Matthieu Falqu...
BMCBI
2011
14 years 4 months ago
Accurate statistics for local sequence alignment with position-dependent scoring by rare-event sampling
Background: Molecular database search tools need statistical models to assess the significance for the resulting hits. In the classical approach one asks the question how probable...
Stefan Wolfsheimer, Inke Herms, Sven Rahmann, Alex...
IANDC
2011
148views more  IANDC 2011»
14 years 4 months ago
Building species trees from larger parts of phylogenomic databases
Abstract. Gene trees are leaf-labeled trees inferred from molecular sequences. Due to duplication events arising in genome evolution, gene trees usually have multiple copies of som...
Celine Scornavacca, Vincent Berry, Vincent Ranwez
TMI
2010
219views more  TMI 2010»
14 years 4 months ago
Registration of 4D Cardiac CT Sequences Under Trajectory Constraints With Multichannel Diffeomorphic Demons
Abstract--We propose a framework for the nonlinear spatiotemporal registration of 4D time-series of images based on the Diffeomorphic Demons (DD) algorithm. In this framework, the ...
Jean-Marc Peyrat, Herve Delingette, Maxime Sermesa...
BMCBI
2011
14 years 1 months ago
Inference of Chromosome-Specific Copy Numbers Using Population Haplotypes
Background: Using microarray and sequencing platforms, a large number of copy number variations (CNVs) have been identified in humans. In practice, because our human genome is a d...
Yao-Ting Huang, Min-Han Wu