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» Computing with Evolving Proteins
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ISMB
1994
14 years 11 months ago
Neural Networks for Determining Protein Specificity and Multiple Alignment of Binding Sites
Weuse a quantitative definition of specificity to developa neural networkfor the identification of commonprotein binding sites in a collection of unaligned DNAfragments. Wedemonst...
John M. Heumann, Alan S. Lapedes, Gary D. Stormo
RECOMB
2004
Springer
15 years 10 months ago
The evolutionary capacity of protein structures
In nature, one finds large collections of different protein sequences exhibiting roughly the same three-dimensional structure, and this observation underpins the study of structur...
Leonid Meyerguz, David Kempe, Jon M. Kleinberg, Ro...
TCBB
2010
104views more  TCBB 2010»
14 years 8 months ago
Fast Hinge Detection Algorithms for Flexible Protein Structures
— Analysis of conformational changes is one of the keys to the understanding of protein functions and interactions. For the analysis, we often compare two protein structures, tak...
Tetsuo Shibuya
99
Voted
RECOMB
2005
Springer
15 years 10 months ago
Predicting Protein-Peptide Binding Affinity by Learning Peptide-Peptide Distance Functions
Many important cellular response mechanisms are activated when a peptide binds to an appropriate receptor. In the immune system, the recognition of pathogen peptides begins when th...
Chen Yanover, Tomer Hertz
80
Voted
BIBM
2008
IEEE
175views Bioinformatics» more  BIBM 2008»
15 years 4 months ago
Integrative Protein Function Transfer Using Factor Graphs and Heterogeneous Data Sources
We propose a novel approach for predicting protein functions of an organism by coupling sequence homology and PPI data between two (or more) species with multifunctional Gene Onto...
Antonina Mitrofanova, Vladimir Pavlovic, Bud Mishr...