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» Computing with Evolving Proteins
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SIBGRAPI
2008
IEEE
15 years 4 months ago
Structural Matching of 2D Electrophoresis Gels using Graph Models
2D electrophoresis is a well known method for protein separation which is extremely useful in the field of proteomics. Each spot in the image represents a protein accumulation an...
Alexandre Noma, Alvaro Pardo, Roberto Marcondes Ce...
APBC
2004
166views Bioinformatics» more  APBC 2004»
14 years 11 months ago
THEMATICS is Effective for Active Site Prediction in Comparative Model Structures
THEMATICS (Theoretical Microscopic Titration Curves) is a simple, reliable computational predictor of the active sites of enzymes from structure. Our method, based on well-establi...
Ihsan A. Shehadi, Alper Uzun, Leonel F. Murga, Val...
BMCBI
2008
172views more  BMCBI 2008»
14 years 10 months ago
Classification of drug molecules considering their IC50 values using mixed-integer linear programming based hyper-boxes method
Background: A priori analysis of the activity of drugs on the target protein by computational approaches can be useful in narrowing down drug candidates for further experimental t...
Pelin Armutlu, Muhittin Emre Ozdemir, Fadime Ü...
BIOINFORMATICS
2005
140views more  BIOINFORMATICS 2005»
14 years 10 months ago
Profile-based direct kernels for remote homology detection and fold recognition
Motivation: Remote homology detection between protein sequences is a central problem in computational biology. Supervised learning algorithms based on support vector machines are ...
Huzefa Rangwala, George Karypis
CORR
2010
Springer
124views Education» more  CORR 2010»
14 years 7 months ago
Lattice model refinement of protein structures
To find the best lattice model representation of a given full atom protein structure is a hard computational problem. Several greedy methods have been suggested where results are ...
Martin Mann, Alessandro Dal Palù