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» Computing with Evolving Proteins
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RECOMB
2006
Springer
15 years 10 months ago
Assessing Significance of Connectivity and Conservation in Protein Interaction Networks
Computational and comparative analysis of protein-protein interaction (PPI) networks enable understanding of the modular organization of the cell through identification of functio...
Mehmet Koyutürk, Ananth Grama, Wojciech Szpan...
105
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BIBM
2010
IEEE
156views Bioinformatics» more  BIBM 2010»
14 years 8 months ago
Truncation of protein sequences for fast profile alignment with application to subcellular localization
We have recently found that the computation time of homology-based subcellular localization can be substantially reduced by aligning profiles up to the cleavage site positions of s...
Man-Wai Mak, Wei Wang, Sun-Yuan Kung
IMSCCS
2007
IEEE
15 years 4 months ago
Evolutionary Conservation of DNA-Contact residues in DNA-binding Domains
Background: DNA-binding proteins are of utmost importance to gene regulation. The identification of DNA-binding domains is useful for understanding the regulation mechanisms of DN...
Yao-Lin Chang, Huai-Kuang Tsai, Cheng-Yan Kao, Yun...
AB
2007
Springer
15 years 4 months ago
Cascaded Games
We introduce a novel model construction, cascaded games, that is intended to allow us to study the notion of steady states algebraically and structurally. The model construction is...
Jittisak Senachak, Mun'delanji Vestergaard, Ren&ea...
CSB
2005
IEEE
136views Bioinformatics» more  CSB 2005»
15 years 3 months ago
An Algebraic Geometry Approach to Protein Structure Determination from NMR Data
Our paper describes the first provably-efficient algorithm for determining protein structures de novo, solely from experimental data. We show how the global nature of a certain ...
Lincong Wang, Ramgopal R. Mettu, Bruce Randall Don...