Accurately aligning distant protein sequences is notoriously difficult. A recent approach to improving alignment accuracy is to use additional information such as predicted seconda...
We describe an algorithm, IsoRank, for global alignment of two protein-protein interaction (PPI) networks. IsoRank aims to maximize the overall match between the two networks; in c...
A novel method to model and predict the location and orientation of alpha helices in membrane- spanning proteins is presented. It is based on a hidden Markov model (HMM) with an a...
Erik L. L. Sonnhammer, Gunnar von Heijne, Anders K...
Background: Hidden Markov Models (HMMs) have proven very useful in computational biology for such applications as sequence pattern matching, gene-finding, and structure prediction...
Abstract. Sequence to structure alignment is an important step in homology modeling of protein structures. Incorporation of features like secondary structure, solvent accessibility...
Chun-Nam John Yu, Thorsten Joachims, Ron Elber, Ja...