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» Computing with Evolving Proteins
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BIOINFORMATICS
2008
119views more  BIOINFORMATICS 2008»
14 years 10 months ago
Optimal design of thermally stable proteins
Motivation: For many biotechnological purposes, it is desirable to redesign proteins to be more structurally and functionally stable at higher temperatures. For example, chemical ...
Ryan M. Bannen, Vanitha Suresh, George N. Phillips...
75
Voted
BMCBI
2010
132views more  BMCBI 2010»
14 years 10 months ago
Protein network prediction and topological analysis in Leishmania major as a tool for drug target selection
Background: Leishmaniasis is a virulent parasitic infection that causes a worldwide disease burden. Most treatments have toxic side-effects and efficacy has decreased due to the e...
Andrés F. Flórez, Daeui Park, Jong B...
BMCBI
2008
142views more  BMCBI 2008»
14 years 10 months ago
Optimal neighborhood indexing for protein similarity search
Background: Similarity inference, one of the main bioinformatics tasks, has to face an exponential growth of the biological data. A classical approach used to cope with this data ...
Pierre Peterlongo, Laurent Noé, Dominique L...
102
Voted
BMCBI
2007
155views more  BMCBI 2007»
14 years 10 months ago
ProCMD: a database and 3D web resource for protein C mutants
Background: Activated Protein C (ProC) is an anticoagulant plasma serine protease which also plays an important role in controlling inflammation and cell proliferation. Several mu...
Pasqualina D'Ursi, Francesca Marino, Andrea Caprer...
89
Voted
SG
2005
Springer
15 years 3 months ago
Generation of Glyphs for Conveying Complex Information, with Application to Protein Representations
Abstract. We present a method to generate glyphs which convey complex information in graphical form. A glyph has a linear geometry which is specified using geometric operations, e...
Greg Pintilie, Brigitte Tuekam, Christopher W. V. ...