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» Computing with Evolving Proteins
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BMCBI
2007
148views more  BMCBI 2007»
14 years 10 months ago
Computation of significance scores of unweighted Gene Set Enrichment Analyses
Background: Gene Set Enrichment Analysis (GSEA) is a computational method for the statistical evaluation of sorted lists of genes or proteins. Originally GSEA was developed for in...
Andreas Keller, Christina Backes, Hans-Peter Lenho...
88
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BMCBI
2005
122views more  BMCBI 2005»
14 years 10 months ago
Computational verification of protein-protein interactions by orthologous co-expression
Background: High-throughput methods identify an overwhelming number of protein-protein interactions. However, the limited accuracy of these methods results in the false identifica...
Itay Tirosh, Naama Barkai
93
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CODES
2005
IEEE
15 years 3 months ago
Blue matter on blue gene/L: massively parallel computation for biomolecular simulation
This paper provides an overview of the Blue Matter application development effort within the Blue Gene project that supports our scientific simulation efforts in the areas of pro...
Robert S. Germain, Blake G. Fitch, Aleksandr Raysh...
68
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BMCBI
2008
106views more  BMCBI 2008»
14 years 10 months ago
Identification of hot-spot residues in protein-protein interactions by computational docking
Background: The study of protein-protein interactions is becoming increasingly important for biotechnological and therapeutic reasons. We can define two major areas therein: the s...
Solène Grosdidier, Juan Fernández-Re...
73
Voted
GECCO
2005
Springer
117views Optimization» more  GECCO 2005»
15 years 3 months ago
A study of evolutionary robustness in stochastically tiled polyominos
Given an evolutionary optimization problem with many possible genotypes for each phenotype this study investigates if the evolved genes for a given phenotype are more robust to po...
Justin Schonfeld, Daniel A. Ashlock