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» Computing with Evolving Proteins
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AE
2001
Springer
15 years 2 months ago
Evolving Objects: A General Purpose Evolutionary Computation Library
This paper presents the evolving objects library (EOlib), an object-oriented framework for evolutionary computation (EC) that aims to provide a flexible set of classes to build EC...
Maarten Keijzer, Juan J. Merelo Guervós, Gu...
87
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GECCO
2004
Springer
137views Optimization» more  GECCO 2004»
15 years 3 months ago
Evolving Better Multiple Sequence Alignments
Aligning multiple DNA or protein sequences is a fundamental step in the analyses of phylogeny, homology and molecular structure. Heuristic algorithms are applied because optimal mu...
Luke Sheneman, James A. Foster
JCC
2008
91views more  JCC 2008»
14 years 9 months ago
An improved pairwise decomposable finite-difference Poisson-Boltzmann method for computational protein design
Abstract: Our goal is to develop accurate electrostatic models that can be implemented in current computational protein design protocols. To this end, we improve upon a previously ...
Christina L. Vizcarra, Naigong Zhang, Shannon A. M...
BMCBI
2007
135views more  BMCBI 2007»
14 years 9 months ago
LIMPIC: a computational method for the separation of protein MALDI-TOF-MS signals from noise
Background: Mass spectrometry protein profiling is a promising tool for biomarker discovery in clinical proteomics. However, the development of a reliable approach for the separat...
Dante Mantini, Francesca Petrucci, Damiana Pierago...
BMCBI
2008
110views more  BMCBI 2008»
14 years 9 months ago
Predikin and PredikinDB: a computational framework for the prediction of protein kinase peptide specificity and an associated da
Background: We have previously described an approach to predicting the substrate specificity of serine-threonine protein kinases. The method, named Predikin, identifies key conser...
Neil F. W. Saunders, Ross I. Brinkworth, Thomas Hu...