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COMPLIFE
2005
Springer
15 years 3 months ago
Fast and Accurate Structural RNA Alignment by Progressive Lagrangian Optimization
During the last few years new functionalities of RNA have been discovered, renewing the need for computational tools for their analysis. To this respect, multiple sequence alignmen...
Markus Bauer, Gunnar W. Klau, Knut Reinert
BMCBI
2010
131views more  BMCBI 2010»
14 years 10 months ago
A comparison of approximation techniques for variance-based sensitivity analysis of biochemical reaction systems
Background: Sensitivity analysis is an indispensable tool for the analysis of complex systems. In a recent paper, we have introduced a thermodynamically consistent variance-based ...
Hong-Xuan Zhang, John Goutsias
BMCBI
2007
233views more  BMCBI 2007»
14 years 10 months ago
160-fold acceleration of the Smith-Waterman algorithm using a field programmable gate array (FPGA)
Background: To infer homology and subsequently gene function, the Smith-Waterman (SW) algorithm is used to find the optimal local alignment between two sequences. When searching s...
Isaac T. S. Li, Warren Shum, Kevin Truong
JCB
2006
144views more  JCB 2006»
14 years 10 months ago
Modeling Virus Self-Assembly Pathways: Avoiding Dynamics Using Geometric Constraint Decomposition
We develop a model for elucidating the assembly pathways by which an icosahedral viral shell forms from 60 identical constituent protein monomers. This poorly understood process a...
Meera Sitharam, Mavis Agbandje-Mckenna
BMCBI
2011
14 years 5 months ago
Logical Development of the Cell Ontology
Background: The Cell Ontology (CL) is an ontology for the representation of in vivo cell types. As biological ontologies such as the CL grow in complexity, they become increasingl...
Terrence F. Meehan, Anna Maria Masci, Amina Abdull...