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» Computing with Evolving Proteins
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BMCBI
2010
154views more  BMCBI 2010»
14 years 7 months ago
Knowledge-based matrix factorization temporally resolves the cellular responses to IL-6 stimulation
Background: External stimulations of cells by hormones, cytokines or growth factors activate signal transduction pathways that subsequently induce a re-arrangement of cellular gen...
Andreas Kowarsch, Florian Blöchl, Sebastian B...
109
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BMCBI
2010
126views more  BMCBI 2010»
14 years 7 months ago
PETALS: Proteomic Evaluation and Topological Analysis of a mutated Locus' Signaling
Background: Colon cancer is driven by mutations in a number of genes, the most notorious of which is Apc. Though much of Apc's signaling has been mechanistically identified o...
Gürkan Bebek, Vishal Patel, Mark R. Chance
NAR
2011
225views Computer Vision» more  NAR 2011»
14 years 17 days ago
Gramene database in 2010: updates and extensions
Now in its 10th year, the Gramene database (http:// www.gramene.org) has grown from its primary focus on rice, the first fully-sequenced grass genome, to become a resource for maj...
Ken Youens-Clark, Edward S. Buckler, Terry M. Cass...
NAR
2011
198views Computer Vision» more  NAR 2011»
14 years 17 days ago
PhylomeDB v3.0: an expanding repository of genome-wide collections of trees, alignments and phylogeny-based orthology and paralo
The growing availability of complete genomic sequences from diverse species has brought about the need to scale up phylogenomic analyses, including the reconstruction of large col...
Jaime Huerta-Cepas, Salvador Capella-Gutiér...
COCOA
2011
Springer
13 years 9 months ago
Algorithmic Aspects of Heterogeneous Biological Networks Comparison
Biological networks are commonly used to model molecular activity within the cell. Recent experimental studies have shown that the detection of conserved subnetworks across several...
Guillaume Blin, Guillaume Fertin, Hafedh Mohamed-B...