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NIPS
2007
14 years 11 months ago
Mining Internet-Scale Software Repositories
Large repositories of source code create new challenges and opportunities for statistical machine learning. Here we first develop Sourcerer, an infrastructure for the automated c...
Erik Linstead, Paul Rigor, Sushil Krishna Bajracha...
BMCBI
2010
104views more  BMCBI 2010»
14 years 10 months ago
Parameters for accurate genome alignment
Background: Genome sequence alignments form the basis of much research. Genome alignment depends on various mundane but critical choices, such as how to mask repeats and which sco...
Martin C. Frith, Michiaki Hamada, Paul Horton
BMCBI
2007
124views more  BMCBI 2007»
14 years 10 months ago
Analysis on multi-domain cooperation for predicting protein-protein interactions
Background: Domains are the basic functional units of proteins. It is believed that protein-protein interactions are realized through domain interactions. Revealing multi-domain c...
Rui-Sheng Wang, Yong Wang, Ling-Yun Wu, Xiang-Sun ...
BMCBI
2007
142views more  BMCBI 2007»
14 years 10 months ago
Improving model construction of profile HMMs for remote homology detection through structural alignment
Background: Remote homology detection is a challenging problem in Bioinformatics. Arguably, profile Hidden Markov Models (pHMMs) are one of the most successful approaches in addre...
Juliana S. Bernardes, Alberto M. R. Dávila,...
BMCBI
2006
95views more  BMCBI 2006»
14 years 10 months ago
Discrete profile comparison using information bottleneck
Sequence homologs are an important source of information about proteins. Amino acid profiles, representing the position-specific mutation probabilities found in profiles, are a ri...
Sean O'Rourke, Gal Chechik, Robin Friedman, Eleaza...