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BMCBI
2010
133views more  BMCBI 2010»
14 years 12 months ago
Predicting enzyme targets for cancer drugs by profiling human Metabolic reactions in NCI-60 cell lines
Background: Drugs can influence the whole metabolic system by targeting enzymes which catalyze metabolic reactions. The existence of interactions between drugs and metabolic react...
Limin Li, Xiaobo Zhou, Wai-Ki Ching, Ping Wang
BMCBI
2008
143views more  BMCBI 2008»
14 years 12 months ago
catmap: Case-control And TDT Meta-Analysis Package
Background: Risk for complex disease is thought to be controlled by multiple genetic risk factors, each with small individual effects. Meta-analyses of several independent studies...
Kristin K. Nicodemus
CSB
2005
IEEE
124views Bioinformatics» more  CSB 2005»
15 years 5 months ago
Discovering Functional Transcription Factor Binding from Superimposed Gene Networks
The availability of entire genome sequences, coupled with genome-wide studies of gene expression, offers promise for discovering new pathways along with their regulatory programs....
Matthew T. Weirauch, Joshua M. Stuart
CSB
2005
IEEE
189views Bioinformatics» more  CSB 2005»
15 years 5 months ago
Learning Yeast Gene Functions from Heterogeneous Sources of Data Using Hybrid Weighted Bayesian Networks
We developed a machine learning system for determining gene functions from heterogeneous sources of data sets using a Weighted Naive Bayesian Network (WNB). The knowledge of gene ...
Xutao Deng, Huimin Geng, Hesham H. Ali
BMCBI
2005
113views more  BMCBI 2005»
14 years 11 months ago
Normal uniform mixture differential gene expression detection for cDNA microarrays
Background: One of the primary tasks in analysing gene expression data is finding genes that are differentially expressed in different samples. Multiple testing issues due to the ...
Nema Dean, Adrian E. Raftery