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» Contextual alignment of biological sequences
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108
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RECOMB
2006
Springer
16 years 25 days ago
Structural Alignment of Pseudoknotted RNA
In this paper, we address the problem of discovering novel non-coding RNA (ncRNA) using primary sequence, and secondary structure conservation, focusing on ncRNA families with pseu...
Banu Dost, Buhm Han, Shaojie Zhang, Vineet Bafna
RECOMB
2005
Springer
16 years 25 days ago
Using Multiple Alignments to Improve Gene Prediction
The multiple species de novo gene prediction problem can be stated as follows: given an alignment of genomic sequences from two or more organisms, predict the location and structur...
Samuel S. Gross, Michael R. Brent
102
Voted
TCBB
2008
95views more  TCBB 2008»
15 years 13 days ago
Solving the Problem of Trans-Genomic Query with Alignment Tables
Abstract-- The trans-genomic query (TGQ) problem -- enabling the free query of biological information, even across genomes -- is a central challenge facing bioinformatics. Solution...
Douglas Stott Parker Jr., Ruey-Lung Hsiao, Yi Xing...
108
Voted
BMCBI
2007
142views more  BMCBI 2007»
15 years 19 days ago
Improving model construction of profile HMMs for remote homology detection through structural alignment
Background: Remote homology detection is a challenging problem in Bioinformatics. Arguably, profile Hidden Markov Models (pHMMs) are one of the most successful approaches in addre...
Juliana S. Bernardes, Alberto M. R. Dávila,...
SIGMOD
2004
ACM
109views Database» more  SIGMOD 2004»
16 years 20 days ago
Piers: An Efficient Model for Similarity Search in DNA Sequence Databases
Growing interest in genomic research has resulted in the creation of huge biological sequence databases. In this paper, we present a hash-based pier model for efficient homology s...
Xia Cao, Shuai Cheng Li, Beng Chin Ooi, Anthony K....