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» Contextual alignment of biological sequences
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NAR
2008
101views more  NAR 2008»
14 years 11 months ago
RNALogo: a new approach to display structural RNA alignment
Regulatory RNAs play essential roles in many essential biological processes, ranging from gene regulation to protein synthesis. This work presents a web-based tool, RNALogo, to cr...
Tzu-Hao Chang, Jorng-Tzong Horng, Hsien-Da Huang
83
Voted
RECOMB
2003
Springer
16 years 25 days ago
Designing seeds for similarity search in genomic DNA
Large-scale comparison of genomic DNA is of fundamental importance in annotating functional elements of genomes. To perform large comparisons efficiently, BLAST (Methods: Companio...
Jeremy Buhler, Uri Keich, Yanni Sun
145
Voted
WABI
2009
Springer
142views Bioinformatics» more  WABI 2009»
15 years 7 months ago
Back-Translation for Discovering Distant Protein Homologies
Background: Frameshift mutations in protein-coding DNA sequences produce a drastic change in the resulting protein sequence, which prevents classic protein alignment methods from ...
Marta Gîrdea, Laurent Noé, Gregory Ku...
107
Voted
RECOMB
2010
Springer
14 years 10 months ago
Novel Definition and Algorithm for Chaining Fragments with Proportional Overlaps
Chaining fragments is a crucial step in genome alignment. Existing chaining algorithms compute a maximum weighted chain with no overlaps allowed between adjacent fragments. In prac...
Raluca Uricaru, Alban Mancheron, Eric Rivals
112
Voted
SAC
2009
ACM
15 years 7 months ago
A new protein motif extraction framework based on constrained co-clustering
Signal finding (pattern discovery) in biological sequences is a fundamental problem in both computer science and molecular biology. Many approaches have been proposed for extract...
Francesca Cordero, Alessia Visconti, Marco Botta