Background: The increasing number of sequenced genomes provides the basis for exploring the genetic and functional diversity within the tree of life. Only a tiny fraction of the e...
Tina Koestler, Arndt von Haeseler, Ingo Ebersberge...
Background: Amino acid sequence probability distributions, or profiles, have been used successfully to predict secondary structure and local structure in proteins. Profile models ...
Background: The rapid development of structural genomics has resulted in many "unknown function" proteins being deposited in Protein Data Bank (PDB), thus, the functiona...
Background: A number of studies on biological networks have been carried out to unravel the topological characteristics that can explain the functional importance of network nodes...
Background: Present-day `-omics' technologies produce overwhelming amounts of data which include genome sequences, information on gene expression (transcripts and proteins) a...
Maria Luisa Chiusano, Nunzio D'Agostino, Alessandr...