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» Current approaches to gene regulatory network modelling
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BMCBI
2010
139views more  BMCBI 2010»
15 years 1 months ago
A highly efficient multi-core algorithm for clustering extremely large datasets
Background: In recent years, the demand for computational power in computational biology has increased due to rapidly growing data sets from microarray and other high-throughput t...
Johann M. Kraus, Hans A. Kestler
BMCBI
2010
126views more  BMCBI 2010»
14 years 11 months ago
PETALS: Proteomic Evaluation and Topological Analysis of a mutated Locus' Signaling
Background: Colon cancer is driven by mutations in a number of genes, the most notorious of which is Apc. Though much of Apc's signaling has been mechanistically identified o...
Gürkan Bebek, Vishal Patel, Mark R. Chance
MIE
2008
131views Healthcare» more  MIE 2008»
15 years 3 months ago
Supervised Approach to Recognize Question Type in a QA System for Health
Many attempts have been made in the QA domain but no system applicable to the field of health is currently available on the Internet. This paper describes a bilingual French/Engli...
Sarah Cruchet, Arnaud Gaudinat, Célia Boyer
GECCO
2009
Springer
15 years 8 months ago
Multiobjectivization for parameter estimation: a case-study on the segment polarity network of drosophila
Mathematical modeling for gene regulative networks (GRNs) provides an effective tool for hypothesis testing in biology. A necessary step in setting up such models is the estimati...
Tim Hohm, Eckart Zitzler
GECCO
2010
Springer
191views Optimization» more  GECCO 2010»
15 years 6 months ago
Initialization parameter sweep in ATHENA: optimizing neural networks for detecting gene-gene interactions in the presence of sma
Recent advances in genotyping technology have led to the generation of an enormous quantity of genetic data. Traditional methods of statistical analysis have proved insufficient i...
Emily Rose Holzinger, Carrie C. Buchanan, Scott M....