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» Current approaches to gene regulatory network modelling
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BMCBI
2010
138views more  BMCBI 2010»
15 years 1 months ago
Sigma-2: Multiple sequence alignment of non-coding DNA via an evolutionary model
Background: While most multiple sequence alignment programs expect that all or most of their input is known to be homologous, and penalise insertions and deletions, this is not a ...
Gayathri Jayaraman, Rahul Siddharthan
BMCBI
2008
122views more  BMCBI 2008»
15 years 1 months ago
Reconstructing networks of pathways via significance analysis of their intersections
Background: Significance analysis at single gene level may suffer from the limited number of samples and experimental noise that can severely limit the power of the chosen statist...
Mirko Francesconi, Daniel Remondini, Nicola Nerett...
SAT
2009
Springer
95views Hardware» more  SAT 2009»
15 years 8 months ago
Finding Lean Induced Cycles in Binary Hypercubes
Induced (chord-free) cycles in binary hypercubes have many applications in computer science. The state of the art for computing such cycles relies on genetic algorithms, which are,...
Yury Chebiryak, Thomas Wahl, Daniel Kroening, Leop...
BMCBI
2010
165views more  BMCBI 2010»
15 years 1 months ago
MTar: a computational microRNA target prediction architecture for human transcriptome
Background: MicroRNAs (miRNAs) play an essential task in gene regulatory networks by inhibiting the expression of target mRNAs. As their mRNA targets are genes involved in importa...
Vinod Chandra, Reshmi Girijadevi, Achuthsankar S. ...
TCBB
2008
103views more  TCBB 2008»
15 years 1 months ago
DNA Motif Representation with Nucleotide Dependency
The problem of discovering novel motifs of binding sites is important to the understanding of gene regulatory networks. Motifs are generally represented by matrices (PWM or PSSM) o...
Francis Y. L. Chin, Henry C. M. Leung