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CPHYSICS
2006
127views more  CPHYSICS 2006»
14 years 9 months ago
GenAnneal: Genetically modified Simulated Annealing
A modification of the standard Simulated Annealing (SA) algorithm is presented for finding the global minimum of a continuous multidimensional, multimodal function. We report resu...
Ioannis G. Tsoulos, Isaac E. Lagaris
JMLR
2012
13 years 8 days ago
Metric and Kernel Learning Using a Linear Transformation
Metric and kernel learning arise in several machine learning applications. However, most existing metric learning algorithms are limited to learning metrics over low-dimensional d...
Prateek Jain, Brian Kulis, Jason V. Davis, Inderji...
BMCBI
2010
161views more  BMCBI 2010»
14 years 7 months ago
Addressing the Challenge of Defining Valid Proteomic Biomarkers and Classifiers
Background: The purpose of this manuscript is to provide, based on an extensive analysis of a proteomic data set, suggestions for proper statistical analysis for the discovery of ...
Mohammed Dakna, Keith Harris, Alexandros Kalousis,...
BMCBI
2011
14 years 4 months ago
Dr. PIAS: an integrative system for assessing the druggability of protein-protein interactions
Background: The amount of data on protein-protein interactions (PPIs) available in public databases and in the literature has rapidly expanded in recent years. PPI data can provid...
Nobuyoshi Sugaya, Toshio Furuya
BMCBI
2010
146views more  BMCBI 2010»
14 years 10 months ago
Nonnegative principal component analysis for mass spectral serum profiles and biomarker discovery
Background: As a novel cancer diagnostic paradigm, mass spectroscopic serum proteomic pattern diagnostics was reported superior to the conventional serologic cancer biomarkers. Ho...
Henry Han