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94
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BMCBI
2006
92views more  BMCBI 2006»
15 years 13 days ago
Demonstration of two novel methods for predicting functional siRNA efficiency
Background: siRNAs are small RNAs that serve as sequence determinants during the gene silencing process called RNA interference (RNAi). It is well know that siRNA efficiency is cr...
Peilin Jia, Tieliu Shi, Yu-Dong Cai, Yixue Li
100
Voted
BMCBI
2006
123views more  BMCBI 2006»
15 years 13 days ago
Computational models with thermodynamic and composition features improve siRNA design
Background: Small interfering RNAs (siRNAs) have become an important tool in cell and molecular biology. Reliable design of siRNA molecules is essential for the needs of large fun...
Svetlana A. Shabalina, Alexey N. Spiridonov, Aleks...
97
Voted
BMCBI
2010
104views more  BMCBI 2010»
15 years 15 days ago
A novel scoring function for discriminating hyperthermophilic and mesophilic proteins with application to predicting relative th
Background: The ability to design thermostable proteins is theoretically important and practically useful. Robust and accurate algorithms, however, remain elusive. One critical pr...
Yunqi Li, C. Russell Middaugh, Jianwen Fang
101
Voted
BMCBI
2004
133views more  BMCBI 2004»
15 years 7 days ago
Esub8: A novel tool to predict protein subcellular localizations in eukaryotic organisms
Background: Subcellular localization of a new protein sequence is very important and fruitful for understanding its function. As the number of new genomes has dramatically increas...
Qinghua Cui, Tianzi Jiang, Bing Liu, Songde Ma
BMCBI
2008
111views more  BMCBI 2008»
15 years 15 days ago
Information-based methods for predicting gene function from systematic gene knock-downs
Background: The rapid annotation of genes on a genome-wide scale is now possible for several organisms using high-throughput RNA interference assays to knock down the expression o...
Matthew T. Weirauch, Christopher K. Wong, Alexandr...