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BMCBI
2005
132views more  BMCBI 2005»
15 years 5 months ago
Kalign - an accurate and fast multiple sequence alignment algorithm
Background: The alignment of multiple protein sequences is a fundamental step in the analysis of biological data. It has traditionally been applied to analyzing protein families f...
Timo Lassmann, Erik L. L. Sonnhammer
143
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BMCBI
2005
127views more  BMCBI 2005»
15 years 5 months ago
Dynamic modeling of cis-regulatory circuits and gene expression prediction via cross-gene identification
Background: Gene expression programs depend on recognition of cis elements in promoter region of target genes by transcription factors (TFs), but how TFs regulate gene expression ...
Li-Hsieh Lin, Hsiao-Ching Lee, Wen-Hsiung Li, Bor-...
149
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BMCBI
2005
122views more  BMCBI 2005»
15 years 5 months ago
Quantitative analysis of EGR proteins binding to DNA: assessing additivity in both the binding site and the protein
Background: Recognition codes for protein-DNA interactions typically assume that the interacting positions contribute additively to the binding energy. While this is known to not ...
Jiajian Liu, Gary D. Stormo
142
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BMCBI
2005
141views more  BMCBI 2005»
15 years 5 months ago
Construction and validation of the APOCHIP, a spotted oligo-microarray for the study of beta-cell apoptosis
Background: Type 1 diabetes mellitus (T1DM) is a autoimmune disease caused by a long-term negative balance between immune-mediated beta-cell damage and beta-cell repair/regenerati...
Nils E. Magnusson, Alessandra K. Cardozo, Mogens K...
BMCBI
2005
101views more  BMCBI 2005»
15 years 5 months ago
PALSSE: A program to delineate linear secondary structural elements from protein structures
Background: The majority of residues in protein structures are involved in the formation of helices and -strands. These distinctive secondary structure patterns can be used to rep...
Indraneel Majumdar, S. Sri Krishna, Nick V. Grishi...
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