Next Generation Sequencing machines are generating millions of short DNA sequences (reads) everyday. There is a need for efficient algorithms to map these sequences to the referen...
Sanchit Misra, Ramanathan Narayanan, Simon Lin, Al...
During recent years there has been an explosive growth of biological data coming from genome projects, proteomics, protein structure determination, and the rapid expansion in digi...
Nasreddine Hireche, J. M. Pierre Langlois, Gabriel...
Background: In ribonucleic acid (RNA) molecules whose function depends on their final, folded three-dimensional shape (such as those in ribosomes or spliceosome complexes), the se...
We present a system of programs designed to facilitate sequence analysis projects involving large amounts of data. SEALS (System for Easy Analysis of Lots of Sequences) is a logic...
Background: Small interfering RNAs (siRNAs) have become an important tool in cell and molecular biology. Reliable design of siRNA molecules is essential for the needs of large fun...
Svetlana A. Shabalina, Alexey N. Spiridonov, Aleks...