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» Detecting Motifs from Sequences
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110
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CSB
2003
IEEE
15 years 3 months ago
Haplotype Motifs: An Algorithmic Approach to Locating Evolutionarily Conserved Patterns in Haploid Sequences
The promise of plentiful data on common human genetic variations has given hope that we will be able to uncover genetic factors behind common diseases that have proven difficult ...
Russell Schwartz
BMCBI
2004
177views more  BMCBI 2004»
14 years 9 months ago
Gapped alignment of protein sequence motifs through Monte Carlo optimization of a hidden Markov model
Background: Certain protein families are highly conserved across distantly related organisms and belong to large and functionally diverse superfamilies. The patterns of conservati...
Andrew F. Neuwald, Jun S. Liu
85
Voted
BIOCOMP
2006
14 years 11 months ago
Insight of the Signal Motif of GPI-(like)-anchored Proteins by using SVM
- Many proteins contain a signal sequence at their COOH-terminus recognized by glycosylphosphatidylinositol (GPI) anchor and attached on the membrane. Experimental result suggests ...
Wei Cao, Kazuya Sumikoshi, Tohru Terada, Shugo Nak...
BMCBI
2005
306views more  BMCBI 2005»
14 years 9 months ago
A method for aligning RNA secondary structures and its application to RNA motif detection
Background: Alignment of RNA secondary structures is important in studying functional RNA motifs. In recent years, much progress has been made in RNA motif finding and structure a...
Jianghui Liu, Jason Tsong-Li Wang, Jun Hu, Bin Tia...
BMCBI
2007
142views more  BMCBI 2007»
14 years 9 months ago
Improving model construction of profile HMMs for remote homology detection through structural alignment
Background: Remote homology detection is a challenging problem in Bioinformatics. Arguably, profile Hidden Markov Models (pHMMs) are one of the most successful approaches in addre...
Juliana S. Bernardes, Alberto M. R. Dávila,...